Objective: This research was to know the activity of Ethanol extract of Sonchus arvensis (Linn.) leaves in inhibiting the angiotensin converting enzyme (ACE) activity. ACE is an enzyme that functions to convert the Angiotensin I into Angiotensin II.
The Angiotensin II has a role in the process of hypertension, it has a strong vasoconstriction effect inducting the hypertension.
Methods: The ethanol extract of Sonchus arvensis (Linn.) was made through the maceration method with ethanol 96% as solvent.
The inhibition extract activity of ACE activity was evaluated using N-hippuryl-L-histidyl-L-leucine (HHL) as a substrate and
will be cleaved by ACE. The inhibitory activity of ethanol extract of Sonchus arvensis (Linn.) leaves towards ACE was calculated
based on the number of hypural acid was created and calculated based on the absorbance value at 228 nm wavelength measured using spectrophotometer UV. The results: The ethanol extract of Sonchus arvensis (Linn.) has inhibition activity ACE at IC50 46.71 μg/ml and IC50 from captopril as a reference drug in 1,26 μg/ml. Therefore, it can be said that the inhibitory activity of Ethanol extract was lower that captopril. Conclusion: Sonchus arvensis (Linn.) is potentially used as the ACE inhibitor and is potential to be developed as antihypertension.