ABSTRACT
Objective: The objective of this study is to test diuretic effect of ethanol extract of P. acidus leaves in female Wistar rats using modification of Lipschitz method.
Methods: The doses of the extract were 22.5, 45 and 90 mg/kg bw. Parameter of diuretic effect was cumulative urine volume during 6 and 24 hours after administration of the extract. Sodium and potassium level in urine were analyzed using atomic absorption spectrophotometry (AAS). The results were analyzed with Student-t test.
Results: The ethanol extracts of P. acidus at doses of 22.5, 45, and 90 mg/kg bw could accelerate the urinary in rats since 60 minutes after oral administration compared to the control and furosemide 3.6 mg/kg bw (P