Abstract.

Stevia rebaudiana is famous as a natural sweetener and potentially lowers blood sugar. The benefits of S. rebaudiana are numerous, and various pharmacological activities have been found, such as efforts to treat diseases such as diabetes, obesity, dental caries, hypoglycemia, and hypertension. The main sweet compounds in S. rebaudiana are rebaudioside A and stevioside, especially in the leaves. This review examines phytochemistry, pharmacological activity, micropropagation, and in-vitro culture modification of S.rebaudiana plants. Online and offline literature searches were conducted to compile the articles. PubMed (Medline), Web of Science, is used to retrieve online publications using the following search terms: S.rebaudiana, stevia herbs, traditional medicine, pharmacological activities, toxicity, secondary metabolite content, phytochemicals, and plant tissue culture of S. rebaudiana. This review is also a compilation of four previous reviews and the latest data from research journals on S. rebaudiana

Keywords: stevioside, rebaudioside A, natural sweetener, lowering blood sugar, plant tissue ulture